In response to changes in Formula One regulations, Ferrari adapted their large engine for the 1952 375 Indianapolis Indy car. With the addition of three new Weber 40IF4C carburettors, the engine's power output increased to 380 hp. The car featured a lengthened wheelbase and a strengthened chassis and suspension. Despite promising European tests, the 375 Indianapolis faced challenges in America, with only one of four cars qualifying for the 1952 Indianapolis 500. That car, driven by Alberto Ascari, started 25th with a qualifying speed of 134.3 mph. Ascari was classified 31st, retiring after 40 laps due to wheel failure. Despite this setback, Ascari dominated the rest of the Formula One season, winning the remaining six Grands Prix and securing his first World Championship, ahead of Ferrari teammate Giuseppe Farina.